4-Fluoroaniline → N-(4-fluorophenyl)-2-[[2-[(4-fluorophenyl)carbamoyl]phenyl]disulfanyl]benzamide

HRID 3719

Reaktionsgleichung

Reaktionsgleichung von HRID 3719
[C:1](Cl)(=[O:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8][S:9][C:10]1[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=1[C:12](Cl)=[O:13].[F:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][CH:23]=1>ClCCl.N1C=CC=CC=1>[F:21][C:22]1[CH:28]=[CH:27][C:25]([NH:26][C:1](=[O:19])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=2[S:8][S:9][C:10]2[CH:18]=[CH:17][CH:16]=[CH:15][C:11]=2[C:12]([NH:26][C:25]2[CH:27]=[CH:28][C:22]([F:21])=[CH:23][CH:24]=2)=[O:13])=[CH:24][CH:23]=1

Komponenten

5

Edukt 2

HCID 97314-FluoroanilineHCID 881642,2'-Dithiodibenzoyl chloride

Produkt 1

HCID 465337N-(4-fluorophenyl)-2-[[2-[(4-fluorophenyl)carbamoyl]phenyl]disulfanyl]benzamideAusbeute 9,7 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1049PyridineLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

This compound was prepared according to the general method of Example 77 using 2,2'-dithiobisbenzoyl chloride (1.00 g, 2.92 mmol) in 20 mL of dichloromethane and 4-fluoroaniline (0.657 g, 5.91 mmol) in 5 mL of pyridine. The crude product was triturated with hot ethanol-ethyl acetate mixture, filtered, and recrystallized from ethanol-DMF to yield 0.14 g of the title compound, mp 242°-244° C.

Aufarbeitung

  1. customThis compound was prepared
  2. customThe crude product was triturated with hot ethanol-ethyl acetate mixture
  3. filtrationfiltered
  4. customrecrystallized from ethanol-DMF

Quellen und Nachweise

ORD-Eintrag
ord-1e404142def44ea88cbeeff7e6caace1
Quelldatensatz
uspto-grants-1998_03
Patentnummer
US05734081

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