Benzene → 3-Cyclopropylcarbonyl-1-phenyl-3-azabicyclo[3.1.0]hexane

HRID 371932Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 371932
[C:1]1([C:7]23[CH2:12][CH:11]2[CH2:10][NH:9][CH2:8]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1C=CC=CC=1.C(N(CC)CC)C.[CH:26]1([C:29](Cl)=[O:30])[CH2:28][CH2:27]1>O>[CH:26]1([C:29]([N:9]2[CH2:10][CH:11]3[C:7]([C:1]4[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=4)([CH2:12]3)[CH2:8]2)=[O:30])[CH2:28][CH2:27]1

Komponenten

6

Edukt 4

HCID 241Benzene2×HCID 8471TriethylamineHCID 77637Cyclopropanecarbonyl chlorideHCID 101300941-Phenyl-3-azabicyclo[3.1.0]hexane

Produkt 1

HCID 128913673-Cyclopropylcarbonyl-1-phenyl-3-azabicyclo[3.1.0]hexane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To a solution of 15.9 g. of 1-phenyl-3-azabicyclo-[3.1.0]hexane in 100 ml. of benzene and 20 ml. of triethylamine is added 11.0 g. of cyclopropanecarboxylic acid chloride in 20 ml. of benzene over 5 minutes. The mixture is stirred for 30 minutes and 50 ml. of water is added. The benzene layer is extracted with dilute sodium bicarbonate followed by dilute hydrochloric acid and then water, dried over magnesium sulfate and evaporated to give the product as a brown oil.

Aufarbeitung

  1. extractionThe benzene layer is extracted with dilute sodium bicarbonate
  2. dry with materialwater, dried over magnesium sulfate
  3. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-6c7e786f5e7246dd812b2581f5b5eec3
Quelldatensatz
uspto-grants-1978_05
Patentnummer
US04088652

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