Dimethylformamide → 2,4-Bis(trifluoromethyl)benzaldehyde

HRID 373359

Reaktionsgleichung

Reaktionsgleichung von HRID 373359
C([N-]C(C)C)(C)C.[Li+].[F:9][C:10]([F:22])([F:21])[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=1.CN(C)[CH:25]=[O:26]>O1CCCC1>[F:9][C:10]([F:21])([F:22])[C:11]1[CH:12]=[C:13]([C:17]([F:18])([F:19])[F:20])[CH:14]=[CH:15][C:16]=1[CH:25]=[O:26]

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 223106Benzene, 1,3-bis(trifluoromethyl)-HCID 2724682Lithium diisopropylamide

Produkt 1

HCID 27360952,4-Bis(trifluoromethyl)benzaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 100 ml (0.21 mol) of lithium diisopropylamide in tetrahydrofuran is cooled under argon to -70° and at this temperature there are added dropwise thereto while stirring 31 ml (0.2 mol) of 1,3-bis(trifluoromethyl)benzene. The resulting dark red, viscous suspension is stirred at -70° for a further 30 minutes and then 31 ml (0.4 mol) of N,N-dimethylformamide are allowed to flow in rapidly. The internal temperature rises to -20° as a consequence of the exothermic reaction in spite of continuous cooling. The violet solution obtained is then processed further as described in Example 3a). 2,4-Bis(trifluoromethyl)-benzaldehyde is obtained.

Aufarbeitung

  1. additionare added dropwise
  2. customThe internal temperature rises to -20° as a consequence of the exothermic reaction in spite of continuous cooling
  3. customThe violet solution obtained

Quellen und Nachweise

ORD-Eintrag
ord-1b729bf16c434f409cdeaf069cac7456
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05162577

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