Dimethylhydantoin → Nilutamide

HRID 374125

Reaktionsgleichung

Reaktionsgleichung von HRID 374125
[CH3:1][C:2]1([CH3:9])[NH:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[N+:10]([C:13]1[CH:18]=[CH:17][C:16](Cl)=[CH:15][C:14]=1[C:20]([F:23])([F:22])[F:21])([O-:12])=[O:11]>C(O)C.[Cu]>[F:21][C:20]([F:22])([F:23])[C:14]1[CH:15]=[C:16]([N:4]2[C:3](=[O:8])[C:2]([CH3:9])([CH3:1])[NH:6][C:5]2=[O:7])[CH:17]=[CH:18][C:13]=1[N+:10]([O-:12])=[O:11]

Komponenten

5

Edukt 2

HCID 6491DimethylhydantoinHCID 670525-Chloro-2-nitrobenzotrifluoride

Produkt 1

HCID 4493Nilutamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23978CopperKatalysatorHCID 702EthanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
200 °C

Versuchsvorschrift

71.5 grams of copper in powder form were added to 96.10 grams of 5,5-dimethyl-hydantoin and 170.86 grams of 2-nitro-5-chloro trifluoromethylbenzene. The mixture was heated to 200° C. for about 21 hours, the pressure being maintained at 450 millibars, then, was cooled to 20° C. and taken up in 480 ml of ethanol. The product was characterized and determined by thin layer chromatography of the ethanol solution.

Aufarbeitung

  1. temperaturethe pressure being maintained at 450 millibars
  2. temperaturewas cooled to 20° C.

Quellen und Nachweise

ORD-Eintrag
ord-f33c2a567db743aeaaf8f1ed8c025a89
Quelldatensatz
uspto-grants-1992_11
Patentnummer
US05166358

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