Nitric Acid → HCID 14405001, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11].[N+:12]([O-])([OH:14])=[O:13]>C(O)(=O)C.ClCCl>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([N+:12]([O-:14])=[O:13])[C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11]Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
20 g of 2,6-dichloro-3,5-difluorophenol are initially introduced in 70 ml of acetic acid, and 8 g of 98% strength nitric acid are added dropwise. Stirring is subsequently continued at room temperature for 2 hours, and the mixture is taken up in 150 ml of dichloromethane and washed twice with water. After the dichloromethane has been distilled off, 18 g of product remain. Purity 94% according to GC analysis.
Aufarbeitung
- washwashed twice with water
- distillationAfter the dichloromethane has been distilled off
Quellen und Nachweise
- ORD-Eintrag
- ord-8a10768ac2cf409bbb96233cc6b7a57e
- Quelldatensatz
- uspto-grants-1992_11
- Patentnummer
- US05166392
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