Trifluoroacetic acid → Caprine

HRID 374684

Reaktionsgleichung

Reaktionsgleichung von HRID 374684
C([O:5][C:6](=[O:13])[C@H:7]([CH2:9][CH2:10][CH2:11][CH3:12])[NH2:8])(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH2:8][C@H:7]([C:6]([OH:13])=[O:5])[CH2:9][CH2:10][CH2:11][CH3:12]

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 12451446tert-butyl (2S)-2-aminohexanoate

Produkt 1

HCID 21236Caprine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

23.5 mg of L-N-[(2R or S)-5-ethylthio-2-(1-naphthylmethyl)pentanoyl]norleucine tert-butyl ester was dissolved in 0.2 ml of dichloromethane, and 0.1 ml of trifluoro acetic acid was added thereto. The mixture was stirred at room temperature for four hours. Then, the reaction solution was concentrated under reduced pressure to obtain 20.7 mg of L-N-[(2R or S)-5-ethylthio-2-(1-naphthylmethyl)pentanoyl]norleucine as colorless solid.

Aufarbeitung

  1. concentrationThen, the reaction solution was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-aa312e5f1bd544c6952f2a6f19a3f20f
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05481036

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