Pyridine → 2-[(1,1-Dimethylethyl)oxy]-6-chlorobenzoyl chloride

HRID 374961Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 374961
[CH3:1][C:2]([O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:7]=1[C:8](O)=[O:9])([CH3:4])[CH3:3].N1C=CC=CC=1.C(Cl)(=O)C([Cl:25])=O>C(#N)C>[CH3:1][C:2]([O:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:7]=1[C:8]([Cl:25])=[O:9])([CH3:4])[CH3:3]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 65578Oxalyl chlorideHCID 189963762-[(1,1-Dimethylethyl)oxy]-6-chlorobenzoic acid

Produkt 1

HCID 189963812-[(1,1-Dimethylethyl)oxy]-6-chlorobenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

2-[(1,1-dimethylethyl)oxy]-6-chlorobenzoic acid (68.6 mg, 0.3 mmol) was weighed into a 1 dram septum-capped vial containing a micro stir bar under nitrogen. Dry acetonitrile (300 microliter), dry pyridine (24 microliter, 0.3 mmol) and oxalyl chloride (26 microliter, 0.3 mmol) were added in order to the vial using microliter syringes. The yellow homogeneous solution was stirred for 30 minutes to afford a solution of 2-[(1,1-dimethylethyl)oxy]-6-chlorobenzoyl chloride.

Aufarbeitung

  1. customseptum-capped vial
  2. additioncontaining a micro stir bar under nitrogen

Quellen und Nachweise

ORD-Eintrag
ord-8b539eb3fffa421bbe814e73e4d9a995
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05482974

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