Hydrochloric Acid → Methyl 2-[(5-amino-6-chloro-1,2-benzisoxazol-3-yl)oxy]propionate, hydrochloride salt

HRID 375067Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 375067
[Cl:1][C:2]1[C:17]([N+:18]([O-])=O)=[CH:16][C:5]2[C:6]([O:9][CH:10]([CH3:15])[C:11]([O:13][CH3:14])=[O:12])=[N:7][O:8][C:4]=2[CH:3]=1.Cl.[H][H]>[Pd].C(O)C>[ClH:1].[NH2:18][C:17]1[C:2]([Cl:1])=[CH:3][C:4]2[O:8][N:7]=[C:6]([O:9][CH:10]([CH3:15])[C:11]([O:13][CH3:14])=[O:12])[C:5]=2[CH:16]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 22402917Methyl 2-[(6-chloro-5-nitro-1,2-benzisoxazol-3-yl)oxy]propionateHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 131719244Methyl 2-[(5-amino-6-chloro-1,2-benzisoxazol-3-yl)oxy]propionate, hydrochloride salt

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A suspension of methyl 2-[(6-chloro-5-nitro-1,2-benzisoxazol-3-yl)oxy]propionate (2.0 g, 6.7 mmol), 5% palladium on activated carbon (0.1 g) and concentrated hydrochloric acid (0.6 mL) in ethanol is hydrogenated until 430 mL of hydrogen is taken up. The reaction mixture is then filtered through diatomaceous earth and concentrated in vacuo to give the title product as a brown gum which is identified by NMR spectral analyses.

Aufarbeitung

  1. filtrationThe reaction mixture is then filtered through diatomaceous earth
  2. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-70bd94d66a5c49eb8cc82faabcea7b22
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05484763

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