Ethylamine → N-Ethyl-2-(4-nitro-1H-imidazol-1-yl)octanoamide

HRID 375113

Reaktionsgleichung

Reaktionsgleichung von HRID 375113
[N+:1]([C:4]1[N:5]=[CH:6][N:7]([CH:9]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:10]([O:12]CC)=O)[CH:8]=1)([O-:3])=[O:2].[CH2:21]([NH2:23])[CH3:22]>C(O)C>[CH2:21]([NH:23][C:10](=[O:12])[CH:9]([N:7]1[CH:8]=[C:4]([N+:1]([O-:3])=[O:2])[N:5]=[CH:6]1)[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[CH3:22]

Komponenten

4

Edukt 2

HCID 6341EthylamineHCID 10062368Ethyl 2-(4-nitro-1H-imidazole-1-yl)octanoate

Produkt 1

HCID 15222339N-Ethyl-2-(4-nitro-1H-imidazol-1-yl)octanoamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethyl 2-(4-nitro-1H-imidazol-1-yl)octanoate (17 moles, 5.0 g) and ethylamine (20 ml) were stirred in 150 ml ethanol at room temperature for 16 hours. The reaction was added to ice water, extracted with ethyl acetate, washed with water, dried over sodium sulfate and concentrated. The oil crystallized upon standing to yield 3.9 g of N-Ethyl-2-(4-nitro-1H-imidazol-1-yl)octanoamide. (MS).

Aufarbeitung

  1. extractionextracted with ethyl acetate
  2. washwashed with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. customThe oil crystallized

Quellen und Nachweise

ORD-Eintrag
ord-fd4c582d41ef494f8ba2e0064e6fd39f
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05484780

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