Chlorine → 1-Chloro-2-(difluoromethoxy)benzene

HRID 375287

Reaktionsgleichung

Reaktionsgleichung von HRID 375287
[F:1][CH:2]([F:10])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[Cl:11]Cl>FC(F)(F)C1C=CC=C(C(F)(F)F)C=1.[Cl-].[K+]>[Cl:11][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[O:3][CH:2]([F:10])[F:1]

Komponenten

5

Edukt 2

HCID 24526Chlorine2×HCID 68015(Difluoromethoxy)benzene2×

Produkt 1

HCID 134050971-Chloro-2-(difluoromethoxy)benzene

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 4873Potassium ChlorideKatalysatorHCID 223106Benzene, 1,3-bis(trifluoromethyl)-Lösungsmittel

Versuchsvorschrift

0.5 g of potassium chloride and 10 g of difluoromethoxybenzene in 100 ml of 1,3-bistrifluoromethylbenzene were introduced as the initial charge, and chlorine was then introduced at 100° C. with UV irradiation. In the course of an hour, another 20 g of difluoromethoxybenzene were metered in. After chlorine uptake was complete, the reaction mixture was purged with nitrogen and subsequently distilled. 35.5 g of chlorodifluoromethoxybenzene were isolated (boiling point 144° C., refractive index nD20 1.4479).

Aufarbeitung

  1. additioninitial charge
  2. customIn the course of an hour
  3. customthe reaction mixture was purged with nitrogen
  4. distillationsubsequently distilled

Quellen und Nachweise

ORD-Eintrag
ord-ce9e40feb79b4bcab347a1604d5df2cc
Quelldatensatz
uspto-grants-1996_01
Patentnummer
US05484932

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