Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → Methyl-(E)-3-(1-methyl-1,2,3-triazol-4-yl)acrylate

HRID 376460Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 376460
[CH3:1][N:2]1[CH:6]=[C:5]([CH:7]=O)[N:4]=[N:3]1.[CH3:9][O:10][C:11]([CH:13]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)=[O:12]>ClCCl>[CH3:9][O:10][C:11](=[O:12])/[CH:13]=[CH:7]/[C:5]1[N:4]=[N:3][N:2]([CH3:1])[CH:6]=1

Komponenten

4

Edukt 2

HCID 17453Acetic acid, 2-(triphenylphosphoranylidene)-, methyl esterHCID 143134381-Methyl-1H-1,2,3-triazole-4-carboxaldehyde

Produkt 1

HCID 21202730Methyl-(E)-3-(1-methyl-1,2,3-triazol-4-yl)acrylateAusbeute 212,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1-Methyl-1,2,3-triazol-4-carboxaldehyde (1 g, 9 mmol) was added to a solution of methoxycarbonylmethylene triphenylphosphorane (4.5 g, 13.5 mmol) in dichloromethane (50 ml) and stirred at room temperature for 3.5 hours. The solvent was removed and the residue purified by silica gel chromatography to afford the title compound, (3.2 g).

Aufarbeitung

  1. customThe solvent was removed
  2. customthe residue purified by silica gel chromatography

Quellen und Nachweise

ORD-Eintrag
ord-306f5d0ea46a40ce95e15948c0726ac3
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06020368

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