Oxalyl chloride → 1-Methylpiperidine-3-carbonyl chloride

HRID 376462Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 376462
[CH3:1][N:2]1[CH2:10][CH2:9][CH2:8][CH:4]([C:5](O)=[O:6])[CH2:3]1.C(Cl)(=O)C([Cl:14])=O>ClCCl.CN(C=O)C>[CH3:1][N:2]1[CH2:10][CH2:9][CH2:8][CH:4]([C:5]([Cl:14])=[O:6])[CH2:3]1

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 27369371-methylpiperidine-3-carboxylic Acid

Produkt 1

HCID 200260181-Methylpiperidine-3-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The hydrochloride salt of (±)-N-methylnipecotic acid (1.0 g) was suspended in dichloromethane (25 ml) and stirred at room temperature for 2 h with oxalyl chloride (0.58 ml) and DMF (1 drop). The solvent was then evaporated to yield the hydrochloride salt of N-methylnipecotyl chloride as a pale yellow solid.

Aufarbeitung

  1. customThe solvent was then evaporated

Quellen und Nachweise

ORD-Eintrag
ord-38471196f515436496682fd4efba0d12
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06020368

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