HCID 18403070, Verbindung → HCID 9903422, Verbindung

HRID 377172Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 377172
[CH2:1]([P:5]([CH2:8][CH:9]([C:22]([O:24]CC1C=CC=CC=1)=[O:23])[CH2:10][CH2:11][C:12]([O:14]CC1C=CC=CC=1)=[O:13])(=[O:7])[OH:6])[CH2:2][CH2:3][CH3:4]>O>[CH2:1]([P:5]([CH2:8][CH:9]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[C:22]([OH:24])=[O:23])([OH:7])=[O:6])[CH2:2][CH2:3][CH3:4]

Komponenten

3

Edukt 1

HCID 18403070HCID 18403070, Verbindung

Produkt 1

HCID 9903422HCID 9903422, VerbindungAusbeute 43,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Butyl[2,4-di(benzyloxycarbonyl)butyl]phosphinic acid (2.9 g, 6.5 mmol) in 30 mL of water containing 0.32 g 10% Pd/C was hydrogenated on a Parr hydrogenator at 40 psi for 4.5 hours. The mixture was filtered through a pad of Celite and evaporated under high vacuum to give 2-[(butylhydroxyphosphinyl)methyl]pentanedioic acid (4, R=n-butyl) (0.75 g, 43%) as a clear and colorless viscous oil.

Aufarbeitung

  1. filtrationThe mixture was filtered through a pad of Celite
  2. customevaporated under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-0755e29a660048db9d05192525379926
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06025344

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