Hydrazine hydrate (1:1) → 6-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

HRID 377613

Reaktionsgleichung

Reaktionsgleichung von HRID 377613
O.[NH2:2][NH2:3].Cl[C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[N:8]([CH3:16])[C:7](=[O:17])[CH:6]=1>C(O)C>[NH:2]([C:5]1[N:10]([CH2:11][CH:12]([CH3:14])[CH3:13])[C:9](=[O:15])[N:8]([CH3:16])[C:7](=[O:17])[CH:6]=1)[NH2:3]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 52825666-Chloro-1-isobutyl-3-methylpyrimidine-2,4(1H,3H)-dione

Produkt 1

HCID 193560846-hydrazino-1-isobutyl-3-methyl-2,4(1H,3H)-pyrimidinedione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Hydrazine hydrate (6.5 ml) was added to a solution of 6-chloro-3-methyl-1-(2-methylpropyl)pyrimidine-2,4[1H,3H]-dione (10.0 g) in ethanol (40 ml). The mixture was heated at reflux for 5 hours, cooled to room temperature and then evaporated under reduced pressure. The residue was recrystallised from ethanol to give the subtitle compound (8.8 g).

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 5 hours
  3. customevaporated under reduced pressure
  4. customThe residue was recrystallised from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-0babe5e48b794874b958f26057a9078b
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06028074

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