1-Benzyloxy-3,5-dichloro-4-(3-(4-trifluoromethylbenzamido)propyloxy)benzene → 3,5-Dichloro-4-(3-(4-trifluoromethylbenzamido)propyloxy)phenol

HRID 377726Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 377726
C([O:8][C:9]1[CH:14]=[C:13]([Cl:15])[C:12]([O:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:32])[C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=2)=[C:11]([Cl:33])[CH:10]=1)C1C=CC=CC=1.[H][H]>C(OCC)(=O)C.[Pd]>[Cl:15][C:13]1[CH:14]=[C:9]([OH:8])[CH:10]=[C:11]([Cl:33])[C:12]=1[O:16][CH2:17][CH2:18][CH2:19][NH:20][C:21](=[O:32])[C:22]1[CH:23]=[CH:24][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:27]=1

Komponenten

5

Edukt 2

HCID 220068441-Benzyloxy-3,5-dichloro-4-(3-(4-trifluoromethylbenzamido)propyloxy)benzeneHCID 178418361HCID 178418361, Verbindung2×

Produkt 1

HCID 232183693,5-Dichloro-4-(3-(4-trifluoromethylbenzamido)propyloxy)phenol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

1-Benzyloxy-3,5-dichloro-4-(3-(4-trifluoromethylbenzamido)propyloxy)benzene was dissolved in ethyl acetate, which was put into a reaction vessel, and the air in the vessel was replaced with nitrogen gas. A catalytic amount of 10% palladium on carbon was added, and the nitrogen gas in the vessel was replaced with hydrogen gas, followed by vigorous stirring at room temperature for 24 hours. The hydrogen gas in the vessel was replaced with nitrogen gas, after which the reaction mixture was filtered through cerite and the filtrate was concentrated to give 3,5-dichloro-4-(3-(4-trifluoromethylbenzamido)propyloxy)phenol.

Aufarbeitung

  1. customwhich was put into a reaction vessel
  2. filtrationafter which the reaction mixture was filtered through cerite and the filtrate
  3. concentrationwas concentrated

Quellen und Nachweise

ORD-Eintrag
ord-58e58258b47a4e85b1d822e6e28fc85f
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06028100

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