CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid

HRID 377740

Reaktionsgleichung

Reaktionsgleichung von HRID 377740
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1

Komponenten

4

Edukt 1

HCID 367964CID 367964

Produkt 1

HCID 154877913-(4-Fluorophenyl)-2-methylpropanoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

5% Pd/C (11.0 g) is added to p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mol) in 3.6 l ethanol. The mixture is hydrogenated at room temperature at 40 p.s.i. When the hydrogen uptake ceases, the catalyst is filtered off, and the filtrate is concentrated in vacuo to give the product, p-fluoro-α-methylhydrocinnamic acid, which is used without weighing in the next step.

Aufarbeitung

  1. customis hydrogenated at room temperature at 40 p.s.i
  2. filtrationWhen the hydrogen uptake ceases, the catalyst is filtered off
  3. concentrationthe filtrate is concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-a801ed2c651849f5bf6530bfe49a45db
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06028116

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