CID 367964 → 3-(4-Fluorophenyl)-2-methylpropanoic acid
Reaktionsgleichung
[F:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[C:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:4][CH:3]=1>C(O)C.[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]([CH3:11])[C:8]([OH:10])=[O:9])=[CH:12][CH:13]=1Komponenten
4
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
5% Pd/C (11.0 g) is added to p-fluoro-α-methylcinnamic acid (177.9 g, 0.987 mol) in 3.6 l ethanol. The mixture is hydrogenated at room temperature at 40 p.s.i. When the hydrogen uptake ceases, the catalyst is filtered off, and the filtrate is concentrated in vacuo to give the product, p-fluoro-α-methylhydrocinnamic acid, which is used without weighing in the next step.
Aufarbeitung
- customis hydrogenated at room temperature at 40 p.s.i
- filtrationWhen the hydrogen uptake ceases, the catalyst is filtered off
- concentrationthe filtrate is concentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-a801ed2c651849f5bf6530bfe49a45db
- Quelldatensatz
- uspto-grants-2000_02
- Patentnummer
- US06028116
Notizen zur Reaktion
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