Methanol → 3,4-Dimethylanisole

HRID 377914

Reaktionsgleichung

Reaktionsgleichung von HRID 377914
[CH3:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[CH:6][C:7]=1[CH3:8].[CH3:10]O.[OH-].[K+].CI>O>[CH3:1][C:2]1[CH:3]=[C:4]([O:9][CH3:10])[CH:5]=[CH:6][C:7]=1[CH3:8]

Komponenten

6

Edukt 4

HCID 887MethanolHCID 6328Methyl iodideHCID 72493,4-DimethylphenolHCID 14797Potassium Hydroxide

Produkt 1

HCID 784113,4-DimethylanisoleAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To 3,4-dimethylphenol(19.3 g, 0.16 mol), methanol(150 ml) and KOH(9.65 g, 0.25 mol) were added and then refluxed for 2 hrs. Methyl iodide(36.5 g, 0.25 mol) was added thereto, refluxed for 3 hours and then followed by addition of water(150 ml). The resulting mixture was extracted with ethylacetate and purified by column chromatography to obtain the titled compound.

Aufarbeitung

  1. temperaturerefluxed for 2 hrs
  2. temperaturerefluxed for 3 hours
  3. extractionThe resulting mixture was extracted with ethylacetate
  4. custompurified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-ec61f0ce6933474899cf676405e5abcb
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06028195

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