Trifluoroacetic acid → 1-Methoxy-4,5-dimethyl-2-nitrobenzene

HRID 377915

Reaktionsgleichung

Reaktionsgleichung von HRID 377915
FC(F)(F)C(O)=O.[CH3:8][C:9]1[CH:10]=[C:11]([O:16][CH3:17])[CH:12]=[CH:13][C:14]=1[CH3:15].[N:18]([O-:20])=[O:19].[Na+]>O>[CH3:15][C:14]1[C:9]([CH3:8])=[CH:10][C:11]([O:16][CH3:17])=[C:12]([N+:18]([O-:20])=[O:19])[CH:13]=1

Komponenten

5

Edukt 3

HCID 6422Trifluoroacetic acidHCID 784113,4-DimethylanisoleHCID 23668193Sodium Nitrite

Produkt 1

HCID 193571651-Methoxy-4,5-dimethyl-2-nitrobenzeneAusbeute 55 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Trifluoroacetic acid(250 ml) was added into 3,4-dimethylanisole(17.1 g, 0.13 mol), successively sodium nitrite(16.6 g, 0.24 mol) was added slowly in water bath, and stirred at room temperature for 14 hrs. After trifluoroacetic acid was removed and water was added thereto, the resulting mixture was extracted with ether, and purified by column chromatography to obtain the titled compound.

Aufarbeitung

  1. customAfter trifluoroacetic acid was removed
  2. additionwater was added
  3. extractionthe resulting mixture was extracted with ether
  4. custompurified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-65c7820380f148e6823b876dab1e3971
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06028195

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