N,N-diethyl-m-toluamide → N,N-Diethyl-5-methyl-2-(trimethylsilyl)benzamide

HRID 377998

Reaktionsgleichung

Reaktionsgleichung von HRID 377998
[CH2:1]([N:3]([CH2:13][CH3:14])[C:4](=[O:12])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1)[CH3:2].[CH3:15][Si:16](Cl)([CH3:18])[CH3:17]>>[CH2:13]([N:3]([CH2:1][CH3:2])[C:4](=[O:12])[C:5]1[CH:6]=[C:7]([CH3:11])[CH:8]=[CH:9][C:10]=1[Si:16]([CH3:18])([CH3:17])[CH3:15])[CH3:14]

Komponenten

3

Edukt 2

HCID 4284N,N-diethyl-m-toluamideHCID 6397Chlorotrimethylsilane

Produkt 1

HCID 18630275N,N-Diethyl-5-methyl-2-(trimethylsilyl)benzamideAusbeute 46 %

Versuchsvorschrift

These compounds were prepared from N,N-diethyl-3-methylbenzamide and 2.0 eq TMSCl according to General Method A. Purification by HPLC using 1:9 ethyl acetate/hexanes gave two products. Compound 63 was isolated as 6.0 g of a clear oil, a 46% yield. Compound 64 was isolated as 2.3 g of a clear oil, a 17% yield.

Aufarbeitung

  1. customPurification by HPLC
  2. customgave two products

Quellen und Nachweise

ORD-Eintrag
ord-3091e1651b4f47c68dfd5455a9fe89f9
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06028101

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