1-Phenyl-4-piperidinone → 1-Phenyl-piperidin-4-one oxime

HRID 37849

Reaktionsgleichung

Reaktionsgleichung von HRID 37849
[C:1]1([N:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:15][OH:16]>CO>[C:1]1([N:7]2[CH2:12][CH2:11][C:10](=[N:15][OH:16])[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 4130091-Phenyl-4-piperidinoneHCID 443297Hydroxyamine hydrochloride

Produkt 1

HCID 3438331-Phenyl-piperidin-4-one oximeAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 1-phenyl-piperidin-4-one (180 mg, 1.03 mmol) and hydroxylamine hydrochloride (142 mg, 2.06 mmol) in methanol (10 mL) was heated at reflux for 6 h. The solvent was evaporated and the residue diluted with water. The mixture was extracted with ethyl acetate then the organic phase was washed with water, brine, dried over anhydrous sodium sulfate and concentrated to afford 1-phenyl-piperidin-4-one oxime (0.18 g, 92%) as a liquid.

Aufarbeitung

  1. temperaturewas heated
  2. temperatureat reflux for 6 h
  3. customThe solvent was evaporated
  4. additionthe residue diluted with water
  5. extractionThe mixture was extracted with ethyl acetate
  6. washthe organic phase was washed with water, brine
  7. dry with materialdried over anhydrous sodium sulfate
  8. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-1a67ca0e59ef49e293898d43ff28ca5e
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524705B2

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