Imidazole → Hexaethyldisiloxane

HRID 378653Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 378653
N1[CH:5]=[CH:4]N=C1.[CH2:6]([Si:8](Cl)([CH2:11][CH3:12])[CH2:9][CH3:10])[CH3:7].[OH2:14]>CN(C)C=O>[CH2:6]([Si:8]([O:14][Si:8]([CH2:4][CH3:5])([CH2:9][CH3:10])[CH2:6][CH3:7])([CH2:11][CH3:12])[CH2:9][CH3:10])[CH3:7]

Komponenten

5

Edukt 3

HCID 795ImidazoleHCID 962WaterHCID 13819Chlorotriethylsilane

Produkt 1

HCID 70442Hexaethyldisiloxane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 205 (15 mmol) in dimethylformamide (30 mL) is cooled to 0° C. and treated with imidazole (30 mmol) and triethylsilyl chloride (20 mmol). The resultant solution is warmed to room temperature. After 12 h, the reaction mixture is poured into 300 mL of water and extracted with ether (3×40 mL). The ethereal extracts are washed with water (2×25 mL) and saturated aqueous brine (25 mL), dried over magnesium sulfate and concentrated in vacuo. The residue is purified by flash chromatography to afford 206.

Aufarbeitung

  1. extractionextracted with ether (3×40 mL)
  2. washThe ethereal extracts are washed with water (2×25 mL) and saturated aqueous brine (25 mL)
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe residue is purified by flash chromatography

Quellen und Nachweise

ORD-Eintrag
ord-3576d1207f994321bc9ad398d6e18155
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06031133

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