Hydrazine hydrate (1:1) → (6-Morpholin-4-ylpyrimidin-4-yl)hydrazine

HRID 37892

Reaktionsgleichung

Reaktionsgleichung von HRID 37892
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:3]=1.O.[NH2:15][NH2:16]>C(O)C>[NH:15]([C:2]1[N:7]=[CH:6][N:5]=[C:4]([N:8]2[CH2:13][CH2:12][O:11][CH2:10][CH2:9]2)[CH:3]=1)[NH2:16]

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 7960704-(6-Chloropyrimidin-4-yl)morpholine

Produkt 1

HCID 13393622(6-Morpholin-4-ylpyrimidin-4-yl)hydrazine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

53.0 g (0.27 mol) of 4-(6-chloropyrimidin-4-yl)morpholine are initially charged in 260 ml of ethanol. 132.9 g (2.7 mol) of hydrazine hydrate are added, and the mixture is stirred under reflux for 16 h. The mixture is cooled to RT, and half of the solvent is removed by distillation. The mixture is then cooled to 0° C., and the solid formed is filtered off. The solid is washed with cold ethanol and initially air-dried and then dried under reduced pressure.

Aufarbeitung

  1. temperatureunder reflux for 16 h
  2. customhalf of the solvent is removed by distillation
  3. temperatureThe mixture is then cooled to 0° C.
  4. customthe solid formed
  5. filtrationis filtered off
  6. washThe solid is washed with cold ethanol
  7. custominitially air-dried
  8. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7c389d41bf3a4ef4b3baa8420d5e64df
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524699B2

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