Diethyl[2-(4-nitrophenoxy)ethyl]amine → 4-(2-(Diethylamino)ethoxy)aniline

HRID 379699

Reaktionsgleichung

Reaktionsgleichung von HRID 379699
[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-])=O)=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2]>[C].[Pd].CO>[CH2:1]([N:3]([CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][C:12]([NH2:15])=[CH:11][CH:10]=1)[CH2:4][CH3:5])[CH3:2]

Komponenten

4

Edukt 1

HCID 88294Diethyl[2-(4-nitrophenoxy)ethyl]amine

Produkt 1

HCID 4189324-(2-(Diethylamino)ethoxy)anilineAusbeute 98,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418390HCID 178418390, VerbindungKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

N,N-diethyl-2-(4-nitrophenoxy)ethylamine (28.19 g) was dissolved into methanol (300 ml) and subjected to hydration reaction at ambient pressure by adding 10% palladium carbon catalyst (1.5 g). After completion of hydration reaction, catalyst was removed by filtration. Filtrate was concentrated under vacuum to obtain N,N-diethyl-2-(4-aminophenoxy)ethylamine (24.25 g) as color-less oily substance.

Aufarbeitung

  1. customsubjected to hydration reaction at ambient pressure
  2. customAfter completion of hydration reaction, catalyst
  3. customwas removed by filtration
  4. concentrationFiltrate was concentrated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-72a8bec4006c486aac01b693cc55603e
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06300368B1

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