Ethanol → 5-Bromo-o-toluidine
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([N+:8]([O-])=O)[CH:7]=1.[Cl-].[NH4+].C(O)C.[OH-].[Na+]>[Fe].O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:11])=[C:6]([CH:7]=1)[NH2:8]Komponenten
7
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A slurry of 5-bromo-2-methylnitrobenzene (3.00 g), iron powder (3.11 g), and ammonium chloride (2.97 g), in 3:1 ethanol : water (50 ml) was heated at reflux temperature for 1 hour. The mixture was poured into 10% aqueous sodium hydroxide and filtered through Celite®. The filtrate was then extracted with ethyl acetate, the extracts washed with brine, dried over magnesium sulfate, filtered and evaporated to afford the subtitle compound as an oil (2.64 g).
Aufarbeitung
- temperatureat reflux temperature for 1 hour
- filtrationfiltered through Celite®
- extractionThe filtrate was then extracted with ethyl acetate
- washthe extracts washed with brine
- dry with materialdried over magnesium sulfate
- filtrationfiltered
- customevaporated
Quellen und Nachweise
- ORD-Eintrag
- ord-0afe2c257b8f4b8fba79f5c0eb0868fb
- Quelldatensatz
- uspto-grants-2001_10
- Patentnummer
- US06300352B1
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