Water → 7-Chloro-2H-thieno[2,3-f][1,3]benzodioxole-6-carboxylic acid

HRID 380239Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 380239
[OH2:1].[Cl:2][C:3]1[C:4]2[CH:14]=[C:13]3[O:15][CH2:16][O:17][C:12]3=[CH:11][C:5]=2[S:6][C:7]=1[C:8](Cl)=[O:9]>O1CCOCC1>[Cl:2][C:3]1[C:4]2[CH:14]=[C:13]3[O:15][CH2:16][O:17][C:12]3=[CH:11][C:5]=2[S:6][C:7]=1[C:8]([OH:1])=[O:9]

Komponenten

4

Edukt 2

HCID 962WaterHCID 27576813-Chloro-5,6-methylenedioxybenzothiophene-2-carbonyl chloride

Produkt 1

HCID 183643997-Chloro-2H-thieno[2,3-f][1,3]benzodioxole-6-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

40 ml of water are added to a solution of 70 mmol of the compound of Step A in 250 ml of dioxane. After 20 hours' reflux and then return to ambient temperature, a precipitate forms. After filtration and rinsing with water until neutral, the precipitate is dried over P2O5 under reduced pressure, allowing the expecting product to be isolated.

Aufarbeitung

  1. temperatureAfter 20 hours' reflux
  2. customreturn to ambient temperature
  3. filtrationAfter filtration
  4. washrinsing with water until neutral, the precipitate
  5. dry with materialis dried over P2O5 under reduced pressure
  6. customto be isolated

Quellen und Nachweise

ORD-Eintrag
ord-7f547cf8cb824ce4b1eb138bd2bd2e6d
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06302837B1

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