3-Azido-2-cyanopyridine → 3-Aminopyridine-2-carbonitrile
Reaktionsgleichung
[N:1]([C:4]1[C:5]([C:10]#[N:11])=[N:6][CH:7]=[CH:8][CH:9]=1)=[N+]=[N-]>C(O)C.[Pd]>[NH2:1][C:4]1[C:5]([C:10]#[N:11])=[N:6][CH:7]=[CH:8][CH:9]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of 3-azido-2-cyanopyridine (1.44 g, 9.9 mmol) in ethanol (100 ml) was hydrogenated over palladium on carbon (10%, 50 mg) at room temperature and 3.5 p.s.i for 18 h. The catalyst was filtered off over Celite and the filtrate was concentrated to leave the product (1.16 g). 1H NMR (d6-DMSO) 7.87 (1H, d), 7.33 (1H, dd), 7.22 (1H, d), 6.28 (2H, s).
Aufarbeitung
- filtrationThe catalyst was filtered off over Celite
- concentrationthe filtrate was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-a4a17ec38cef4688a38ac0e63cc42f3b
- Quelldatensatz
- uspto-grants-2001_10
- Patentnummer
- US06303613B1
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