Hydrochloric Acid → 7-Ethyl-5-aminobenzothiazole

HRID 380621

Reaktionsgleichung

Reaktionsgleichung von HRID 380621
Cl[Sn]Cl.Cl.[CH2:5]([C:7]1[C:15]2[S:14][CH:13]=[N:12][C:11]=2[CH:10]=[C:9]([N+:16]([O-])=O)[CH:8]=1)[CH3:6].[OH-].[Na+]>>[CH2:5]([C:7]1[C:15]2[S:14][CH:13]=[N:12][C:11]=2[CH:10]=[C:9]([NH2:16])[CH:8]=1)[CH3:6]

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 24479Stannous ChlorideHCID 227280367-Ethyl-5-nitro-1,3-benzothiazole

Produkt 1

HCID 227280297-Ethyl-5-aminobenzothiazoleAusbeute 98,4 %

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

To a solution of SnCl2 (1.5 g, 1.9 mmol) and 5.0 mL of HCl was added 7-ethyl-5-nitrobenzothiazole (0.12 g, 0.57 mmol) in a portion and resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was basified with aqueous NaOH and extracted with EtOAc and CHCl3. Combined organic layers were dried over Na2SO4 and concentrated in vacuo, yielding an oil (0.10 g, >95%) which was identified as the desired amine (>95% pure) and subjected to a following reaction without further purification.

Aufarbeitung

  1. customresulting
  2. customreaction mixture
  3. extractionextracted with EtOAc and CHCl3
  4. dry with materialCombined organic layers were dried over Na2SO4
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-015e95d803d649e2943d06321edc5868
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06303643B1

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