Iodine → 2-Iodo-4-methylaniline

HRID 380948

Reaktionsgleichung

Reaktionsgleichung von HRID 380948
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][CH:3]=1.C(=O)(O)[O-].[Na+].[I:14]I>C(Cl)Cl.O>[I:14][C:3]1[CH:4]=[C:5]([CH3:8])[CH:6]=[CH:7][C:2]=1[NH2:1]

Komponenten

6

Edukt 3

HCID 807IodineHCID 7813p-ToluidineHCID 516892Sodium Bicarbonate

Produkt 1

HCID 27640002-Iodo-4-methylaniline

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a stirred solution of p-toluidine (5 g, 46.7 mmol) in methylene chloride (25 mL) was added a solution of sodium bicarbonate (4.7 g, 56 mmol) in water (75 mL). Then was added iodine (11.26 g, 44.33 mmol) in small portions and the mixture was stirred for 16 hours at room temperature. The reaction was quenched with saturated NaHSO3 and the product was extracted with methylene chloride. The methylene chloride layer was washed with brine, dried over Na2SO4, and evaporated in vacuo to give a crude 2-iodo-4-methylaniline.

Aufarbeitung

  1. customThe reaction was quenched with saturated NaHSO3
  2. extractionthe product was extracted with methylene chloride
  3. washThe methylene chloride layer was washed with brine
  4. dry with materialdried over Na2SO4
  5. customevaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-761c4f38dbf34caa9dce14ad1d773a04
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06303780B1

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