Hydrazine hydrate (1:1) → HCID 178505870, Verbindung

HRID 38106Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 38106
[CH2:1]([N:8]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:9]1[C:10]([F:29])=[C:11]([C:16](=O)[C:17](=[C:24]2[S:27]CS2)[C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)[C:12]([F:15])=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:38][NH2:39]>C(O)C>[CH2:30]([N:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:9]1[C:10]([F:29])=[C:11]([C:16]2[C:17]([C:18]3[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=3)=[C:24]([SH:27])[NH:38][N:39]=2)[C:12]([F:15])=[CH:13][CH:14]=1)[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1

Komponenten

4

Edukt 2

HCID 24654Hydrazine hydrate (1:1)HCID 584770931-(3-Dibenzylamino-2,6-difluoro-phenyl)-2-[1,3]dithietan-2-ylidene-2-pyridin-4-yl-ethanone

Produkt 1

HCID 178505870HCID 178505870, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

1-(3-Dibenzylamino-2,6-difluoro-phenyl)-2-[1,3]dithietan-2-ylidene-2-pyridin-4-yl-ethanone (1.26 g, 2.44 mmol) was suspended in absolute ethanol (10 mL). Hydrazine monohydrate (0.473 mL, 9.755 mmol, 4 eq) was added dropwise and the mixture was stirred at 60° C. for 2 hours. The suspension was concentrated under reduced pressure, taken up with toluene (2×20 mL) and evaporated to dryness. The crude product (1.35 g) was used in the following step without further purification.

Aufarbeitung

  1. concentrationThe suspension was concentrated under reduced pressure
  2. customevaporated to dryness
  3. customThe crude product (1.35 g) was used in the following step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-07c144564ed04b458143538441abee06
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524707B2

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