Pentafluoropyridine → 2,3,5,6-Tetrafluoro-4-methoxypyridine

Reaktionsgleichung

[F:1][C:2]1[N:7]=[C:6]([F:8])[C:5]([F:9])=[C:4](F)[C:3]=1[F:11].[CH3:12][O-:13].[Na+]>>[CH3:12][O:13][C:4]1[C:3]([F:11])=[C:2]([F:1])[N:7]=[C:6]([F:8])[C:5]=1[F:9]

Komponenten

Edukt 2

HCID 69690Pentafluoropyridine

HCID 10942334Sodium Methoxide

Produkt 1

HCID 139996172,3,5,6-Tetrafluoro-4-methoxypyridine

Versuchsvorschrift

To pentafluoropyridine (1.0 g, 5.9 mmol) in petroleum ether (60 mL) at 0° C. was added sodium methoxide (0.32 mg, 5.9 mmol). After stirring for 12 hours at ambient temperature, the reaction was washed with water, dried (MgSO4), and the solvent was removed in vacuo to give 4-methoxy-2,3,5,6-tetrafluoropyridine; NMR (CDCl3) 4.3 ppm.

Aufarbeitung

washthe reaction was washed with water
dry with materialdried (MgSO4)
customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag: ord-615eff473bbf4d638f832f9423b112e5
Quelldatensatz: uspto-grants-2001_10
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US06306884B1

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