Pentafluoropyridine → 2,3,5,6-Tetrafluoro-4-methoxypyridine

HRID 381450

Reaktionsgleichung

Reaktionsgleichung von HRID 381450
[F:1][C:2]1[N:7]=[C:6]([F:8])[C:5]([F:9])=[C:4](F)[C:3]=1[F:11].[CH3:12][O-:13].[Na+]>>[CH3:12][O:13][C:4]1[C:3]([F:11])=[C:2]([F:1])[N:7]=[C:6]([F:8])[C:5]=1[F:9]

Komponenten

3

Edukt 2

HCID 69690PentafluoropyridineHCID 10942334Sodium Methoxide

Produkt 1

HCID 139996172,3,5,6-Tetrafluoro-4-methoxypyridine

Versuchsvorschrift

To pentafluoropyridine (1.0 g, 5.9 mmol) in petroleum ether (60 mL) at 0° C. was added sodium methoxide (0.32 mg, 5.9 mmol). After stirring for 12 hours at ambient temperature, the reaction was washed with water, dried (MgSO4), and the solvent was removed in vacuo to give 4-methoxy-2,3,5,6-tetrafluoropyridine; NMR (CDCl3) 4.3 ppm.

Aufarbeitung

  1. washthe reaction was washed with water
  2. dry with materialdried (MgSO4)
  3. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-615eff473bbf4d638f832f9423b112e5
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06306884B1

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