(RS)-S-(4-nitrophenyl)-N-(methylcarbamoyl)-S-methylsulfoximide → (RS)-S-(4-aminophenyl)-N-(methylcarbamoyl)-S-methylsulfoximide
Reaktionsgleichung
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH3:17])(=[N:12][C:13](=[O:16])[NH:14][CH3:15])=[O:11])=[CH:6][CH:5]=1)([O-])=O>CO.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10]([CH3:17])(=[N:12][C:13](=[O:16])[NH:14][CH3:15])=[O:11])=[CH:6][CH:5]=1Komponenten
4
Edukt 1
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
302 mg (1.17 mmol) (RS)—S-(4-nitrophenyl)-N-(methylcarbamoyl)-S-methylsulfoximide in 20 ml methanol is hydrogenated over 60 mg palladium (10% on carbon, 50% water wet) for 4 hours at 26° C. and 30 bar. The catalyst is filtered and the solvent evaporated to give 271 mg (corresponding to 100% of theor.) of the product.
Aufarbeitung
- filtrationThe catalyst is filtered
- customthe solvent evaporated
- customto give 271 mg (corresponding to 100% of theor.) of the product
Quellen und Nachweise
- ORD-Eintrag
- ord-dee432b90ff14d21a17b1f3c05355fa7
- Quelldatensatz
- uspto-grants-2013_09
- Patentnummer
- US08524724B2
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