N-methyl-3(R)-[3-[4-(pyndin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid benzyl ester → N-methyl-3(R)-[3-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid

HRID 382174Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 382174
C([O:8][C:9](=[O:33])[CH2:10][C@@H:11]([N:16]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][N:30]=[CH:29][CH:28]=3)=[CH:23][CH:22]=2)=[CH:17]1)[C:12]([NH:14][CH3:15])=[O:13])C1C=CC=CC=1>C(O)(=O)C>[CH3:15][NH:14][C:12](=[O:13])[C@H:11]([N:16]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:28]=[CH:29][N:30]=[CH:31][CH:32]=3)=[CH:23][CH:22]=2)=[CH:17]1)[CH2:10][C:9]([OH:33])=[O:8]

Komponenten

3

Edukt 1

HCID 53874083N-methyl-3(R)-[3-[4-(pyndin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid benzyl ester

Produkt 1

HCID 54315845N-methyl-3(R)-[3-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acidAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

According to the procedure described in Example 7(a), N-methyl-3(R)-[3-[4-(pyridin-4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid benzyl ester was hydrogenolyzed in acetic acid to yield in 90% yield N-methyl-3(R)-[3-[4-(pyridin4-yl)phenyl]-1H-pyrrol-1-yl]succinamic acid as a yellow amorphous solid.

Quellen und Nachweise

ORD-Eintrag
ord-f677a209fe7b450c9c1d59a7ec143cca
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06306892B1

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