Nicotinic Acid → 1-(4-t-Butylbenzyl)-4-(3-pyridylcarbonylamino)-5-imidazolecarboxamide

HRID 382401

Reaktionsgleichung

Reaktionsgleichung von HRID 382401
[NH2:1][C:2]1[N:3]=[CH:4][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:13][CH:12]=2)[C:6]=1[C:7]([NH2:9])=[O:8].[C:21](O)(=[O:28])[C:22]1[CH:27]=[CH:26][CH:25]=[N:24][CH:23]=1>>[C:17]([C:14]1[CH:15]=[CH:16][C:11]([CH2:10][N:5]2[C:6]([C:7]([NH2:9])=[O:8])=[C:2]([NH:1][C:21]([C:22]3[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=3)=[O:28])[N:3]=[CH:4]2)=[CH:12][CH:13]=1)([CH3:20])([CH3:19])[CH3:18]

Komponenten

3

Edukt 2

HCID 938Nicotinic AcidHCID 183602894-Amino-1-(4-t-butylbenzyl)-5-imidazolecarboxamide

Produkt 1

HCID 183606031-(4-t-Butylbenzyl)-4-(3-pyridylcarbonylamino)-5-imidazolecarboxamideAusbeute 70 %

Versuchsvorschrift

An amidation reaction and post-treatment were carried out under the same conditions as in Example 19, using 1.50 g (5.51 mmol) of 4-amino-1-(4-t-butylbenzyl)-5-imidazole carboxamide which was prepared in the same manner as in Example 57 and nicotinic acid instead of cyclopentyl acetic acid to obtain 1.45 g of 1-(4-t-butylbenzyl)-4-(3-pyridylcarbonylamino)-5-imidazolecarboxamide (yield 70%).

Aufarbeitung

  1. customAn amidation reaction

Quellen und Nachweise

ORD-Eintrag
ord-b164a9af74a846d08d9775bf937d66b4
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310070B1

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