Triethylamine → 3-[4-(3-Phenylpropyl)piperazin-1-yl]propanethiol dihydrochloride

HRID 3825Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 3825
NC(N)=[S:3].[ClH:5].Cl.[C:7]1([CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][Cl:25])[CH2:18][CH2:17]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C.[OH-].[Na+]>O.C(O)C>[ClH:25].[ClH:5].[C:7]1([CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][SH:3])[CH2:18][CH2:17]2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

Komponenten

7

Edukt 4

HCID 8471TriethylamineHCID 14798Sodium HydroxideHCID 2723790ThioureaHCID 201531841-(3-Phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride

Produkt 1

HCID 137311283-[4-(3-Phenylpropyl)piperazin-1-yl]propanethiol dihydrochlorideAusbeute 82 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

The procedure described in Example 1(b) was followed, using 19.0 g of thiourea, 44.0 g of 1-(3-phenylpropyl)-4-(3-chloropropyl)piperazine dihydrochloride, 25 g of triethylamine and 250 ml of reagent ethanol. The hydrolysis was effected with 10.0 g of sodium hydroxide in 50 ml of water. Work-up, as described above, gave 35.8 g (82% of theory) of 3-[4-(3-phenylpropyl)piperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 237°-239° C.

Quellen und Nachweise

ORD-Eintrag
ord-63495ea5d1234e62baec2879feb6bdcc
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04722926

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