Hydrochloric Acid → (E)-1-(3-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride

HRID 382512

Reaktionsgleichung

Reaktionsgleichung von HRID 382512
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][N:3]=1.N1C=CC=CC=1[N:15]1[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=2[N:17]=[C:16]1/[CH:24]=[CH:25]/[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.Cl>CO>[ClH:1].[CH3:8][C:7]1[C:2]([N:15]2[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=3[N:17]=[C:16]2/[CH:24]=[CH:25]/[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[N:3][CH:4]=[CH:5][CH:6]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 876032-Chloro-3-methylpyridineHCID 9796241(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole

Produkt 1

HCID 22736672(E)-1-(3-Methylpyrid-2-yl)-2-styryl-1H-benzimidazole hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Free base of the titled compound was prepared from 2-styryl-1-benzimidazole and 2-chloro-3-methylpyridine according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method B). The free base was treated with a 10% methanol solution of hydrogen chloride and concentrated to dryness. The residue was recrystallized from ethyl acetate/n-hexane to give the titled compound.

Aufarbeitung

  1. concentrationconcentrated to dryness
  2. customThe residue was recrystallized from ethyl acetate/n-hexane

Quellen und Nachweise

ORD-Eintrag
ord-c4cac8873b38476388b2519c8f40e940
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310079B1

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