Hydrochloric Acid → (E)-5-Methyl-2-(4-methoxystyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride

HRID 382572

Reaktionsgleichung

Reaktionsgleichung von HRID 382572
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([N+:9]([O-])=O)[CH:3]=1.[CH3:12][O:13][C:14]1[CH:24]=[CH:23][C:17](/[CH:18]=[CH:19]/[C:20]([Cl:22])=O)=[CH:16][CH:15]=1.[N:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1N1C2C=CC=CC=2N=C1/C=C/C1C=CC=CC=1.Cl>CO>[ClH:22].[CH3:1][C:2]1[CH:8]=[CH:7][C:5]2[N:6]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][N:25]=3)[C:20](/[CH:19]=[CH:18]/[C:17]3[CH:23]=[CH:24][C:14]([O:13][CH3:12])=[CH:15][CH:16]=3)=[N:9][C:4]=2[CH:3]=1

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 69784-Methyl-2-nitroanilineHCID 9796241(E)-1-(2-pyridyl)-2-styryl-1H-benzimidazoleHCID 10976422trans-4-Methoxycinnamoyl chloride

Produkt 1

HCID 18360812(E)-5-Methyl-2-(4-methoxystyryl)-1-(2-pyridyl)-1H-benzimidazole hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

Free base of the titled compound was prepared from 4-methyl-2-nitroaniline and (E)-4-methoxycinnamoyl chloride according to the preparation of (E)-1-(2-pyridyl)-2-styryl-1H-benzimidazole (Example 1, method A). The free base was dissolved with a 10% methanol solution of hydrogen chloride (5 ml). Concentration and recrystallization from ethyl acetate/ethanol yielded the titled compound.

Aufarbeitung

  1. concentrationConcentration and recrystallization from ethyl acetate/ethanol

Quellen und Nachweise

ORD-Eintrag
ord-1b3ce5fe73c64cc1b630a5b48c7e592d
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310079B1

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