Methyl 5-bromovalerate → Methyl 5-methoxypentanoate

A solution of methyl 5-bromovalerate (10.0 g, 51.3 mmol), NaOMe (12.3 ml of 25% solution, 53.8 mmol) in 100 ml of MeOH was refluxed for 5 hrs. The MeOH was removed in vacuo and residue was partitioned between CHCl3 (200 ml) and water (50 ml). The organic layer was separated and washed with water (100 ml). After drying (Na2SO4) and evaporation of solvent, methyl 5-methoxyvalerate (7.33 g, 97.8%) was obtained as a colorless oil.

1. customThe MeOH was removed in vacuo and residue
2. customwas partitioned between CHCl3 (200 ml) and water (50 ml)
3. customThe organic layer was separated
4. washwashed with water (100 ml)
5. customAfter drying
6. custom(Na2SO4) and evaporation of solvent

ORD-Eintrag

ord-9ebe57927bed4e27be776e84ed2e595b

Quelldatensatz

uspto-grants-2001_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US06310076B1