Hydrochloric Acid → 4[-2-(4-Benzyl-piperidine-1-yl)-ethanesulfonyl]-phenol hydrochloride

HRID 382780Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 382780
[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:26].C(OCC)C>CCO>[ClH:26].[CH2:1]([CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([OH:25])=[CH:21][CH:20]=2)(=[O:18])=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 97989454[-2-(4-Benzyl-piperidine-1-yl)-ethanesulfonyl]-phenol

Produkt 1

HCID 98870034[-2-(4-Benzyl-piperidine-1-yl)-ethanesulfonyl]-phenol hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
2.5 °C

Versuchsvorschrift

To a solution of 1.15 g 4[-2-(4-benzyl-piperidine-1-yl)-ethanesulfonyl]-phenol (3.2 mmol) in EtOH (5 ml) was added ethanolic HCl (2.6 ml, 1.46 M, 3.8 mmol). The reaction mixture was cooled to 0-5° C. and stirred for 10 min. Then diethyl ether was added until the product precipitated. After filtration 1.14 g of the product (2.9 mmol, 91%) as a white solid was obtained.

Aufarbeitung

  1. customprecipitated
  2. customwas obtained

Quellen und Nachweise

ORD-Eintrag
ord-7a3dcdba32cb402b8adbc0563ad6c208
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310213B1

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