Hydrochloric Acid → Ethyl dodecanoyl-3, 5-dimethylpyrrole-2-carboxylate

HRID 382821Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 382821
[Al+3].[Cl-].[Cl-].[Cl-].[CH3:5][C:6]1[CH:10]=[C:9]([CH3:11])[NH:8][C:7]=1[C:12]([O:14][CH2:15][CH3:16])=[O:13].[C:17](Cl)(=[O:29])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28].Cl>O.ClCCl>[C:17]([C:10]1[C:6]([CH3:5])=[C:7]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[NH:8][C:9]=1[CH3:11])(=[O:29])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28]

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 8166Dodecanoyl chlorideHCID 1374771H-Pyrrole-2-carboxylic acid, 3,5-dimethyl-, ethyl esterHCID 6451240Aluminum(III) Chloride

Produkt 1

HCID 18362055Ethyl dodecanoyl-3, 5-dimethylpyrrole-2-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

1.46 g (11 mmol) of AlCl3 were added to a solution of 1.67 g (10 mmol) of ethyl 3,5-dimethylpyrrole-2-carboxylate a 2.63 g (12 mmol) of dodecanoyl chloride in 30 ml of absol. Dichloromethane and then stirred for 24 h. Addition of water and dilute HCl is followed by extraction twice with CH2Cl2. The organic phases are washed with dilute NaOH, dried over Na2SO4 and concentrated. The product is recrystallized from isopropanol.

Aufarbeitung

  1. extractionis followed by extraction twice with CH2Cl2
  2. washThe organic phases are washed with dilute NaOH
  3. dry with materialdried over Na2SO4
  4. concentrationconcentrated
  5. customThe product is recrystallized from isopropanol

Quellen und Nachweise

ORD-Eintrag
ord-85823facb44a4b2297b82673efd223d8
Quelldatensatz
uspto-grants-2001_10
Patentnummer
US06310217B1

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