Phenylacetyl chloride → [4-Chloro-2-[[(3S)-4-(phenylacetyl)-3-propyl-1-piperazinyl]methyl]-phenoxy]-acetic Acid

Reaktionsgleichung

[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17](S(C3C=CC=CC=3)(=O)=O)[C@@H:16]([CH2:29][CH2:30][CH3:31])[CH2:15]2)[CH:3]=1.[C:32]1([CH2:38][C:39](Cl)=[O:40])[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>>[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([O:6][CH2:7][C:8]([OH:10])=[O:9])=[C:4]([CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:39](=[O:40])[CH2:38][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)[C@@H:16]([CH2:29][CH2:30][CH3:31])[CH2:15]2)[CH:3]=1

Komponenten

Edukt 2

HCID 7679Phenylacetyl chloride

HCID 11597936HCID 11597936, Verbindung

Produkt 1

HCID 11539557[4-Chloro-2-[[(3S)-4-(phenylacetyl)-3-propyl-1-piperazinyl]methyl]-phenoxy]-acetic Acid

Versuchsvorschrift

Prepared from the product from example 72 part (f) (0.70 g) and phenylacetyl chloride according to the procedure described in example 69 part (g) to give the title compound as a white solid (214 mg).

Quellen und Nachweise

ORD-Eintrag: ord-0362b148b29e4e6a8d6012284df9cda1
Quelldatensatz: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08524715B2

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