4-Methylmorpholine → Ethyl[3-(3-{4-[(2-acetylaminoacetylamino)methyl]phenyl}-6-oxo-6h-pyridazin-1-ylmethyl)phenyl]carbamate

HRID 383637Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 383637
[C:1]([NH:4][CH2:5][C:6]([OH:8])=O)(=[O:3])[CH3:2].CN1CCOCC1.ON1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC.[CH2:38]([O:40][C:41](=[O:65])[NH:42][C:43]1[CH:48]=[CH:47][CH:46]=[C:45]([CH2:49][N:50]2[C:55](=[O:56])[CH:54]=[CH:53][C:52]([C:57]3[CH:62]=[CH:61][C:60]([CH2:63][NH2:64])=[CH:59][CH:58]=3)=[N:51]2)[CH:44]=1)[CH3:39]>CN(C=O)C>[CH2:38]([O:40][C:41](=[O:65])[NH:42][C:43]1[CH:48]=[CH:47][CH:46]=[C:45]([CH2:49][N:50]2[C:55](=[O:56])[CH:54]=[CH:53][C:52]([C:57]3[CH:58]=[CH:59][C:60]([CH2:63][NH:64][C:6](=[O:8])[CH2:5][NH:4][C:1](=[O:3])[CH3:2])=[CH:61][CH:62]=3)=[N:51]2)[CH:44]=1)[CH3:39]

Komponenten

7

Edukt 5

HCID 79724-MethylmorpholineHCID 10972AcetylglycineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 59406699Ethyl{3-[3-(4-aminomethylphenyl)-6-oxo-6h-pyridazin-1-ylmethyl]phenyl}carbamate

Produkt 1

HCID 25118490Ethyl[3-(3-{4-[(2-acetylaminoacetylamino)methyl]phenyl}-6-oxo-6h-pyridazin-1-ylmethyl)phenyl]carbamate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

61 mg (0.52 mmol) of N-acetylglycine are suspended in 2 ml of DMF, 106 μl (0.95 mmol) of 4-methylmorpholine, 66 mg (0.47 mmol) of 1-hydroxybenzotriazole and 184 mg (0.95 mmol) of N-(3-dimethylamino-propyl)-N′-ethylcarbodiimide hydrochloride are added. The reaction mixture is stirred at room temperature for 10 min, 180 mg (0.48 mmol) of ethyl{3-[3-(4-aminomethylphenyl)-6-oxo-6H-pyridazin-1-ylmethyl]-phenyl}carbamate are subsequently added, and the mixture is stirred at room temperature for 24 h.

Aufarbeitung

  1. stirringthe mixture is stirred at room temperature for 24 h.

Quellen und Nachweise

ORD-Eintrag
ord-956ff54e833c41dd962f219daf89fbf4
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367668B2

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