HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
1-Benzylpiperazine → 7-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 1-Benzylpiperazine | HCID 75994 | — |
| Edukt | Ethyl 7-bromobenzofuran-2-carboxylate | HCID 46738833 | — |
| Produkt | 7-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester | HCID 59636745 | — |
Reaktionsschritte
The compound was prepared according to the procedure disclosed in Example 1a starting from benzylpiperazine (16.1 mL, 92.6 mmol) and 7-bromo-benzofuran-2-carboxylic acid ethyl ester (16.6 g, 61.7 mmol). The product was purified by flash chromatography (SiO2; hexane/EtOAc, gradient 0-50%). Yield: 14 g (63%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08367676B2 |
| Quelldatensatz | uspto-grants-2013_02 |
| ORD ID | ord-ab2da4472f894810b39b12f88afabf61 |
| Quellennotiz | uspto-grants-2013_02 |