Acetic Acid → 7-(4-(2-(4-Cyanopyridin-2-yl)ethyl)piperazin-1-yl)-N,N-dimethylbenzofuran-2-carboxamide

HRID 383827

Reaktionsgleichung

[CH:1]([C:3]1[CH:4]=[C:5]([CH:8]=[CH:9][N:10]=1)[C:6]#[N:7])=[CH2:2].[CH3:11][N:12]([CH3:30])[C:13]([C:15]1[O:16][C:17]2[C:23]([N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)=[CH:22][CH:21]=[CH:20][C:18]=2[CH:19]=1)=[O:14].C(O)(=O)C>C(O)C>[C:6]([C:5]1[CH:8]=[CH:9][N:10]=[C:3]([CH2:1][CH2:2][N:27]2[CH2:28][CH2:29][N:24]([C:23]3[C:17]4[O:16][C:15]([C:13]([N:12]([CH3:30])[CH3:11])=[O:14])=[CH:19][C:18]=4[CH:20]=[CH:21][CH:22]=3)[CH2:25][CH2:26]2)[CH:4]=1)#[N:7]

Komponenten

Reaktionsbedingungen

Temperatur: 90 °C

Versuchsvorschrift

The compound was prepared according to the procedure disclosed in Example 39 starting from of 2-vinylisonicotinonitrile (0.076 g, 0.59 mmol), N,N-dimethyl-7-(piperazin-1-yl)benzofuran-2-carboxamide (0.080 g, 0.29 mmol) (Example 39d), and acetic acid (0.013 mL, 0.23 mmol). Ethanol was used as solvent and the reaction heated at 90° C. for two days. The crude product was purified by preparative HPLC to give the title compound.

Aufarbeitung

customThe compound was prepared
customThe crude product was purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag: ord-51688835e6bf46c0b7feffc884d64030
Quelldatensatz: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08367676B2

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