Reaktionsgleichung
[OH:1][CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([OH:10])[CH:7]=[CH:8][CH:9]=1.[F:11][C:12]1[N:17]=[CH:16][C:15](B(O)O)=[CH:14][CH:13]=1.C(N(CC)CC)C>C(Cl)(Cl)Cl.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[F:11][C:12]1[N:17]=[CH:16][C:15]([O:10][C:6]2[CH:5]=[C:4]([CH2:3][CH2:2][OH:1])[CH:9]=[CH:8][CH:7]=2)=[CH:14][CH:13]=1Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To a solution of 3-(2-hydroxyethyl)phenol (142.5 mg) in chloroform (5 ml), 279 mg of (6-fluoro-3-pyridinyl)boronic acid, 0.043 ml of triethylamine, 681 mg of copper acetate, and 500 mg of 4A molecular sieve were added, and the reaction solution was stirred at room temperature for 6 days. The reaction solution was filtered through Celite, and the filtrate was diluted with water, extracted with chloroform, and dried over anhydrous magnesium sulfate. The reaction solvent was distilled off under reduced pressure, and the residue obtained was purified by silica gel column chromatography (eluent: ethyl acetate/hexane (0:100-50:50-75/25)) to afford the title compound as a yellow oil.
Aufarbeitung
- filtrationThe reaction solution was filtered through Celite
- additionthe filtrate was diluted with water
- extractionextracted with chloroform
- dry with materialdried over anhydrous magnesium sulfate
- distillationThe reaction solvent was distilled off under reduced pressure
- customthe residue obtained
- customwas purified by silica gel column chromatography (eluent: ethyl acetate/hexane (0:100-50:50-75/25))
Quellen und Nachweise
- ORD-Eintrag
- ord-3f6bf3bb23f34917aa941651a5ed5c94
- Quelldatensatz
- uspto-grants-2013_02
- Patentnummer
- US08367708B2
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