Water → 3-Phenoxy-benzeneethanol

HRID 384130

Reaktionsgleichung

Reaktionsgleichung von HRID 384130
[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][C:15](O)=[O:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O>O1CCCC1.B.O1CCCC1>[O:1]([C:8]1[CH:9]=[C:10]([CH2:14][CH2:15][OH:16])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 2

HCID 962WaterHCID 1417493-Phenoxyphenylacetic acid

Produkt 1

HCID 139291293-Phenoxy-benzeneethanol

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 2723981Borane;tetrahydrofuranLösungsmittel

Versuchsvorschrift

To a solution of (3-phenoxyphenyl)acetic acid (1.157 g) in tetrahydrofuran (23 ml), 6.5 ml of borane-tetrahydrofuran complex (1.17M tetrahydrofuran solution) was added, and the reaction solution was stirred at room temperature for 2 hours. To the reaction solution was added water, and the mixture was extracted with chloroform and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue obtained was purified by silica gel column chromatography (eluent: ethyl acetate/hexane (10:90-80/20)) to afford the title compound as a colorless oil.

Aufarbeitung

  1. extractionthe mixture was extracted with chloroform
  2. dry with materialdried over anhydrous sodium sulfate
  3. distillationThe solvent was distilled off under reduced pressure
  4. customthe residue obtained
  5. customwas purified by silica gel column chromatography (eluent: ethyl acetate/hexane (10:90-80/20))

Quellen und Nachweise

ORD-Eintrag
ord-41d8072ff54f4585ac33d72cb7cc8a8f
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367708B2

Verknüpfte Notizen

Wird geladen…