L-Pyroglutamic Acid → HCID 86649496, Verbindung

HRID 384427

Reaktionsgleichung

Reaktionsgleichung von HRID 384427
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:15]([CH3:17])[CH3:16])[CH:12]([CH3:14])[CH3:13])[CH:7]=1.[NH:25]1[C:29](=[O:30])[CH2:28][CH2:27][C@H:26]1[C:31]([OH:33])=[O:32]>CC(C)=O>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([OH:24])=[C:6]([C@@H:8]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH2:9][CH2:10][N:11]([CH:12]([CH3:14])[CH3:13])[CH:15]([CH3:16])[CH3:17])[CH:7]=1.[NH:25]1[C:29](=[O:30])[CH2:28][CH2:27][C@H:26]1[C:31]([O-:33])=[O:32]

Komponenten

4

Edukt 2

HCID 7405L-Pyroglutamic AcidHCID 443879Tolterodine

Produkt 1

HCID 86649496HCID 86649496, VerbindungAusbeute 82,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel3×

Versuchsvorschrift

3.25 g of tolterodine dissolved in 50 mL of acetone was mixed at room temperature (25° C.) with 1.29 g of L-pyroglutamic acid, which was suspended in 50 mL of acetone, and then stirred. In 10 minutes, there started to appear a solid precipitate. 50 mL of acetone was added thereto and the mixture was stirred at room temperature (25° C.) for 1 hour. The resulting solid precipitate was filtered and then washed with acetone. The resultant was dried at room temperature (25° C.) for 24 hours and 3.74 g (theoretical yield: 82.3%) of the final product in white solid was obtained.

Aufarbeitung

  1. stirringthe mixture was stirred at room temperature (25° C.) for 1 hour
  2. filtrationThe resulting solid precipitate was filtered
  3. washwashed with acetone
  4. customThe resultant was dried at room temperature (25° C.) for 24 hours

Quellen und Nachweise

ORD-Eintrag
ord-61d10679dfec4d6bb30c69427de548b8
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367726B2

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