Hydrochloric Acid → 6-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)nicotinamide dihydrochloride

HRID 38479

Reaktionsgleichung

Reaktionsgleichung von HRID 38479
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:11]=[C:12]3[C:29](=[CH:30][CH:31]=2)[O:28][C:15]2([CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]2)[CH2:14][C:13]3=[O:32])=[N:8][CH:9]=1)(=[O:3])[NH2:2].[ClH:33].CCOCC>O1CCOCC1>[ClH:33].[ClH:33].[O:32]=[C:13]1[C:12]2[C:29](=[CH:30][CH:31]=[C:10]([C:7]3[CH:6]=[CH:5][C:4]([C:1]([NH2:2])=[O:3])=[CH:9][N:8]=3)[CH:11]=2)[O:28][C:15]2([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[CH2:14]1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 58208682tert-Butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylate

Produkt 1

HCID 667818846-(4-Oxospiro[chroman-2,4'-piperidin]-6-yl)nicotinamide dihydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

To a suspension of tert-butyl 6-(5-carbamoylpyridin-2-yl)-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate in dioxane (125 ml) was added 4N HCl in dioxane (125 ml) and the mixture was stirred for 18 h. After Et2O was added to the mixture, the resulted precipitate was collected by aeration, washed with Et2O to give intended compound as a colorless solid.

Aufarbeitung

  1. customthe resulted precipitate was collected by aeration
  2. washwashed with Et2O
  3. customto give

Quellen und Nachweise

ORD-Eintrag
ord-6add63eca05c4a7ea8bd746aa231ffd3
Quelldatensatz
uspto-grants-2013_09
Patentnummer
US08524730B2

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