Morpholine → 1-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanone

HRID 385796Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 385796
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Br:11])[N:6]=1)=[O:4].[NH:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1>O1CCCC1.CN(C)C=O.C(OCC)(=O)C>[Br:11][C:7]1[N:6]=[C:5]([C:3](=[O:4])[CH2:2][N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[CH:10]=[CH:9][CH:8]=1

Komponenten

6

Edukt 2

HCID 8083MorpholineHCID 534075852-Bromo-1-(6-bromopyridin-2-yl)ethan-1-one

Produkt 1

HCID 595263201-(6-Bromopyridin-2-yl)-2-morpholin-4-ylethanone

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 6228DimethylformamideLösungsmittelHCID 8028TetrahydrofuranLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 2-bromo-1-(6-bromopyridin-2-yl)ethanone (250 mg, 0.90 mmol) in tetrahydrofuran (1 mL) and dimethylformamide (1 mL) was added morpholine (0.18 mL, 2.0 mmol). After 45 minutes, the reaction mixture was diluted with ethyl acetate (30 mL) and washed with saturated aqueous sodium bicarbonate (15 mL) and brine (15 mL). The organic layer was dried over sodium sulfate, filtered, and concentrated to afford the title compound.

Aufarbeitung

  1. washwashed with saturated aqueous sodium bicarbonate (15 mL) and brine (15 mL)
  2. dry with materialThe organic layer was dried over sodium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-4c1d8ce65b514d8d8625714bfe11e6e3
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

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