2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 2-{[6-(5,6-Dihydroimidazo[1,2-a]pyrazin-7(8H)-ylcarbonyl)pyridin-2-yl]amino}-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 385881

Reaktionsgleichung

Reaktionsgleichung von HRID 385881
Br[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([N:10]2[CH2:14][CH2:13][C@@H:12](OC)[CH2:11]2)=[O:9])[N:3]=1.[NH2:17][C:18]1[S:19][C:20]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([OH:35])([CH3:34])[CH3:33])=[CH:28][C:27]=2[F:36])=[CH:21][C:22]=1[C:23]([NH2:25])=[O:24]>>[N:3]1[CH:4]=[CH:8][N:10]2[CH2:13][CH2:14][N:10]([C:8]([C:4]3[N:3]=[C:2]([NH:17][C:18]4[S:19][C:20]([C:26]5[CH:31]=[CH:30][C:29]([C:32]([OH:35])([CH3:33])[CH3:34])=[CH:28][C:27]=5[F:36])=[CH:21][C:22]=4[C:23]([NH2:25])=[O:24])[CH:7]=[CH:6][CH:5]=3)=[O:9])[CH2:11][C:12]=12

Komponenten

3

Edukt 2

HCID 582166382-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamideHCID 595256092-bromo-6-{[(3R)-3-methoxypyrrolidin-1-yl]carbonyl}pyridine

Produkt 1

HCID 595257242-{[6-(5,6-Dihydroimidazo[1,2-a]pyrazin-7(8H)-ylcarbonyl)pyridin-2-yl]amino}-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Versuchsvorschrift

The title compound was prepared as described in Example 1 using 2-bromo-6-{[(3R)-3-methoxypyrrolidin-1-yl]carbonyl}pyridine (200 mg, 0.65 mmol) and 2-amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide (192 mg, 0.65 mmol) as starting materials.

Quellen und Nachweise

ORD-Eintrag
ord-c8b6c92f959c49c7b5c00d9c8500ef0c
Quelldatensatz
uspto-grants-2013_02
Patentnummer
US08367706B2

Verknüpfte Notizen

Wird geladen…