Methanol → 2-(6-Bromopyridin-2-yl)-2-methylpropanoic acid
Reaktionsgleichung
[Br:1][C:2]1[N:7]=[C:6]([C:8]([CH3:12])([CH3:11])[C:9]#N)[CH:5]=[CH:4][CH:3]=1.[OH-:13].[Na+].C[OH:16]>C(OCC)(=O)C.O>[Br:1][C:2]1[N:7]=[C:6]([C:8]([CH3:12])([CH3:11])[C:9]([OH:16])=[O:13])[CH:5]=[CH:4][CH:3]=1Komponenten
6
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
To a solution of 2-(6-bromopyridin-2-yl)-2-methylpropanenitrile (Example 367, Step 1) (50 mg, 0.22 mmol) in methanol (2 mL) was added 1 N aqueous sodium hydroxide (2 mL) and the mixture was heated to 80° C. overnight. The reaction was then cooled to ambient temperature, diluted with ethyl acetate (15 mL) and water (15 mL), and the layers were separated. The aqueous layer was acidified with 2 N hydrochloric acid solution and extracted with ethyl acetate (15 mL). The organic layer was dried over sodium sulfate, filtered and concentrated to yield the title compound.
Aufarbeitung
- temperatureThe reaction was then cooled to ambient temperature
- customthe layers were separated
- extractionextracted with ethyl acetate (15 mL)
- dry with materialThe organic layer was dried over sodium sulfate
- filtrationfiltered
- concentrationconcentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-be9854e9a0e040d7828219353d31c3a7
- Quelldatensatz
- uspto-grants-2013_02
- Patentnummer
- US08367706B2
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